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Conversely, it enhances the activity of tumor-suppressive lncRNAs such as MEG3, hence strengthening p53-mediated apoptosis and inhibiting metastasis (Wang W.-H

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This relationship is also evident at a genetic level, as the deletion of fatty acid desaturase 1/2 (FADS1/2) genes in mice showed BD-like behavior with both hypo and hyperactive episodes, which responded to lithium [159]