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Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite Trimethylamine-N-Oxide

Proceedings of the Nutrition Society 74

The significant correlation between the %WR with glucose postprandial excursion but not with insulin/C-peptide postprandial profiles suggests that individuals with higher %WR face an additional challenge to control glucose levels after meals, unsurprisingly given the well-known association of obesity with increased risk of dysglycemia ( We found significantly higher glucose and lower insulin excursions in the T2D relapse subgroup when compared to the T2D remission subgroup

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Some researchers believe that reducing gut inflammation and improving intestinal integrity could indirectly influence mood, cognition, and stress regulation, though this has not been proven clinically

Some patients continue GLP-1 therapy long-term at a maintenance dose to support sustained weight loss