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Give tirzepatide a minimum of 16 weeks at a therapeutic dose (10mg or higher) before evaluating efficacy
Endocrinology (2012) 153:64758
[98] Mood-related side effects, including irritability, anxiety, and depression, have been reported in some patients taking melatonin
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Consequently, most next-generation triagonistsincluding SAR441255, retatrutide, and NN1706are designed with reduced glucagon potency (approximately one-tenth that of GLP-1R activity) to preserve euglycemia while maintaining thermogenic drive [66,139-141]
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