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Initial observations suggest that MC3R might be involved in modulating appetite under certain experimental conditions

121148 (Academic Press, 2007)

About 9% of placebo patients lost at least 10% of their body weight over 36 weeks, while 47% to 75% of orforglipron patients lost at least that amount depending on their designated dosage

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Research has suggested that rapid weight loss from GLP-1 medications can shift fat distribution in ways that affect the sensory nerves near the skin, potentially contributing to sensations like burning, tingling, or increased sensitivity