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LPS can directly and acutely bind to plasma proteins such as fibrinogen to promote the formation of these fibrinaloid microclot deposits (353)

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Strategies such as gradual ascent, preacclimatization, descent, and several pharmacological agents (e.g., acetazolamide, methazolamide, dexamethasone, nifedipine, and sildenafil) are widely accepted as effective strategies for preventing and treating acute altitude illnesses