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Their data were consistent with a GSH transporter-mediated BBB crossing [42]
sALS and fALS progression is clinically and pathologically very similar, both characterized by the progressive accumulation of toxic misfolded protein aggregates within cells [76] and the significant loss of MNs [77]
The incidence of treatment-related adverse events (trAEs) was set as the major measure for the safety outcome
N Engl J Med 2016;375:311-22.ArticlePubMedPMC 35
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Cooney LG, Dokras A
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