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(84) showed that the PKA pathway also mediated the GLP-1-induced inhibition of ANG II signaling on cRAF (Ser 259) in glomerular endothelial cells, providing a further explanation for the renal protective effects of GLP-1

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Es interesante resaltar el hecho de que el aumento de la supervivencia de las clulas cardiacas en respuesta a terapias basadas en GLP-1 tiene un impacto significativo en la funcin cardiaca como se demuestra en la mayora de los estudios mencionados, tanto en el contexto de la isquemia-reperfusin como en el de la IC (tabla 2)25,34,40,42,4451

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