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A case-control study (80 NTD-affected pregnancy and 409 controls) in US women found that the lowest concentrations of serum choline ( 399.5 mg/day) were no different than the lowest intakes ( 8.36 M vs

Insomnia was not among the most prominently reported adverse events in published phase 2 trial data, though gastrointestinal side effects such as nausea may indirectly disrupt sleep

Persistent fatigue combined with muscle weakness, difficulty concentrating, or mood changes warrants evaluation for thyroid dysfunction, anemia, or depression

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