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Description

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Low ROS levels activate cell survival signaling pathways, such as the unfolded protein response and Nrf2 pathways, whereas high ROS levels activate cell death signaling pathways, such as apoptosis and necroptosis pathways 43

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FOXO4-DRI was designed as a competitive interference peptide: a retro-inverso analogue of the FOXO4 region implicated in that contact, joined to a cell-penetrating import segment so the construct can reach the nuclear compartment in cell models

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