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Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

The only thing that changed is the concentration

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10.1242/dev.124.4.925 6 BiedermannB.WrightJ.SenftenM.KalchhauserI.SarathyG.LeeM.-H.et al (2009)

Record concentrations (mg/mL) on all containers, per institutional SOPs

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