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While NAD+ is considered safe at a wide range of doses, higher doses may increase the risk of side effects such as fatigue, nausea, or flu-like symptoms
Alterations in DNA damage repair (DDR) Molecular mechanisms in DDR DDR safeguards genomic stability under genotoxic stress, and its deficiency confers pronounced sensitivity to genotoxic therapies and PARP inhibitors while also driving resistance through repair restoration or pathway bypass
1990 Nov 1;282(2):221-5
Most of what drives the combo narrative is driven by marketing rather than data
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