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Garg notes

human risk uncertain) Timing: GI effects are most prominent during dose increases and typically improve over weeks to months

They may be curious why you eat differently from the family, or why you think you need to change

doi: 10.1136/bcr-2020-241547 [PubMed] 34625331 Cunningham D, Clark K, Lord K

Improved control despite reduced medication: The combination of improved insulin sensitivity plus semaglutides direct effects often produces better glucose control than previous multi-drug regimens

Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide