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doi: 10.1038/nature08821 104 RaoY.KuangZ.LiC.GuoS.XuY.ZhaoD.et al

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Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations

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