Still the most transparent mainstream option
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This review highlights oxidative stress as a key driver of chronic disease and highlights how lifestyle and environmental factors deplete antioxidant capacity
(2023) employed high-performance liquid chromatography-tandem mass spectrometry (LC/MS) to analyze 408 PCOS patients, revealing significantly elevated serum levels of chenodeoxycholic acid (CDCA) and cholic acid (CA), which positively correlated with insulin resistance and hyperandrogenemia
The complete pathway requires further exploration
While some MRS data showed region-specific increases, the overall trend pointed to rising oxidative stress with age (13)