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Researchers use SGLT2-, SGLT1-, URAT1-, and GLUT9-knockout mouse models to investigate the UA-lowering effect of the SGLT2 inhibitor canagliflozin, and show that the mechanism of this effect involved intraluminal glucose transmission and inhibition of the proximal tubule urate transporter URAT1 (Novikov et al., 2019
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Lancet 363 (9423), 17831793
Nagalingam NA, Lynch SV
(2018) 25:R22545
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