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Beyond mechanistic understanding, the safety and efficacy of ferroptosis-related drugs must be validated through rigorous clinical trials
In conclusion, various endogenous and exogenous pathophysiological mechanisms in patients with chronic kidney diseases lead to enhanced activity of oxidative enzymes such as xanthine oxidase (XO), myeloperoxidase (MPO), and the NADPH oxidase enzymes (NOX)
Treat it as what it is: an experimental add-on to a well-designed protocol, not a foundational compound
[ CrossRef ] [ Google scholar ] [ PubMed ] Zhou XM, Wang GL, Wang XB, Liu L, Zhang Q, Yin Y, et al
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