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Because excess weight is closely linked to insulin resistance, fatty liver disease, sleep apnoea, cardiovascular disease, and progression to type 2 diabetes, weight loss achieved with GLP-1 therapy can have wide-ranging metabolic benefits even before diabetes develops
Key metrics to monitor include body weight trends over weeks rather than daily fluctuations, subjective appetite ratings before and after meals, frequency and intensity of cravings throughout the day, energy levels and any changes in fatigue patterns, and digestive symptoms that might indicate the supplement or medication is affecting gut function
Nonetheless, market growth will require a combination of effectiveness, tolerability, safety, acceptability among payers, and proof of cardiometabolic benefits
The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a metaanalysis of randomized controlled trials
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Upregulated expression of CPT1A has also been determined in breast cancer by an integrated genomic strategy based on the use of gene expression signatures of oncogenic pathway activity 20
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