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GLG retrieved the main articles included in the review

Ophthalmology 122(2):254264

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Some methodological details are so fundamental (e.g., brainstem registration, or selection of a baseline reference brain region or metabolite, or choosing between blood serum and cerebrospinal fluid) that they can be completely responsible for a study's results or lack thereof

Only later do they come to understand that surgery provides better results and eliminates the need for medications altogether

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