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Nitric oxide inhibits the mitochondrial carnitine/acylcarnitine carrier through reversible S-nitrosylation of cysteine 136
Mechanistically, TMAO stimulates nuclear factor kappa-B (NF-B) nuclear translocation, thereby enhancing transcriptional upregulation of NLRP3 and other pro-inflammatory genes
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Neither salsalate nor anakinra are yet FDA approved for diabetes (van Poppel 2014
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