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Hyperglycemia, Insulin Resistance, Impaired Pancreatic -Cell Function, and Risk of Pancreatic Cancer

The trials findings also suggest that bofanglutide could help manage diabetes and obesity

The local tissue response and the systemic metabolic effects operate through completely different mechanisms

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or are entering maintenance mode after losing weight with higher doses

While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension ( In summary, while systemic IV DFO is invasive and non-specific for brain delivery for chronic brain iron overload, it may have potential applications for immediate effect and is useful in acute neurological damage where iron is rapidly released and accessible (e.g., acute iron poisoning or ICH)