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Despite these being isolates from patients, only a few strains caused cytotoxicity, reflected in release of the cytoplasmic enzyme lactate dehydrogenase (LDH), of A-431 vulvar epithelial cells in vitro (Fig
For this population-based study, researchers used medical records from about 45 million people in the United States listed in the TriNetX real-time federated health research network who all had at least one outpatient or inpatient doctor visit between 2011 and 2023
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The SmPC also notes that rodent studies showed thyroid C-cell tumours, though the human relevance of this finding is unknown and not established as a human risk
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