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Activation of adenylyl cyclase via Gs leads to an increase in intracellular cAMP, which activates protein kinase A (PKA)

[5] Notably, normal feedback mechanisms remain intact: elevated IGF-1 and GH can signal the hypothalamus and pituitary to modulate further hormone release, which may reduce the risk of extreme hormone levels

This may be explained by the excimer lasers higher irradiance (power per unit area), which is thought to stimulate melanocyte development

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