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Macular complications Although uncommon, some cases of macular edema have been reported while taking GLP-1 receptor agonists, such as semaglutide

in Clinical Pharmacology & Therapeutics found subcutaneous injection reached peak plasma concentration (Tmax) at 75 minutes versus 38 minutes for IM, but area-under-curve (total bioavailability) was statistically equivalent at 94% versus 97%