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This pain is typically constant and can be accompanied by nausea and vomiting

First, it provides direct neurotrophic support, promoting neuronal survival and differentiation

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The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents

Retrieved from Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R, et al