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Key proteostasis pathways, including the UPS, ALP, HSPs, and UPR, are critical for regulating cellular homeostasis under these stress conditions (Fig

In line with patient studies, cellular and mouse models of ALS also showed high levels of ROS, along with elevated oxidation of membrane phospholipids (HNE, MDA), DNA (8-OHdG), and proteins (protein carbonyl groups, 3-NT) [94, 109,110,111]

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