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Cell pellets were then lysed in 50 l of 5% SDS, 100 mM TEAB and sonicated (QSonica) for 5 cycles, with a 1 min resting period on ice after each cycle

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The accumulation of amyloid-beta (A) plaques and the hyperphosphorylation of tau proteins contribute to mitochondrial abnormalities and exacerbate oxidative damage

5 GI events like nausea, diarrhea, constipation, vomiting, and dyspepsia were the most frequently reported adverse effects

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