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Undeniably powerful weight loss in a pen and a pill 1-3 Along with diet and exercise Wegovy HD In adults with obesity, Efficacy estimand: ~21% (20.7%) mean weight loss with Wegovy HD (semaglutide) injection 7.2 mg vs 2.4% with placebo at 72 weeks, in an idealized scenario estimating efficacy if all patients remained on treatment and used no other weight-loss therapies* Treatment regimen estimand: ~19% (18.8%) mean weight loss with Wegovy HD vs 3.9% with placebo at 72 weeks, for all patients in the trial regardless of whether patients stayed on treatment or took other weight-loss therapies For adults taking Wegovy for weight reduction: Those who tolerate the 2.4 mg dosage for at least 4 weeks and additional weight reduction is clinically indicated, the dosage may be increased to a maximum dosage of 7.2 mg subcutaneously once weekly

How are GLP-1s taken

No human trial dose exists Every dose number above comes from rodent studies scaled to a human size or from research community use

However, this initial decrease comes mainly from fluid loss, appetite/eating changes, and potential GI side effects not necessarily fat loss

20 In agreement with the ADA, the American Association of Clinical Endocrinologists (AACE) lists DPP-4 inhibitors as an alternative in patients with an A1C under 7.5% in whom the use of metformin is contraindicated

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