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Unlike systemic IGF-1 LR3, native mechano growth factor has an extremely short half-life, often described in minutes rather than hours, because it is meant to act at the site of damage and then degrade quickly before it can diffuse into general circulation

Kedari KG, Smith Z, Cheli VT, Corral JG, Wang C, Paez PM (2026) Astrocyte-specific deletion of ceruloplasmin exacerbates oxidative stress and demyelination in the spinal cord in a murine model of multiple sclerosis

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(2010), J Int Soc Sports Nutr (DOI) | Abbasi B et al

Weight loss was about 6% lower in men than in women in both groups, the authors noted