Winstel, D., Marchal, A., & Nioi, C
Notable associations were observed with ODC1, MAT2A, AMD1, and ADORA3, genes known to participate in polyamine biosynthesis, methylation pathways, and cellular stress response mechanisms
Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1
Altintas also noted that if these findings are confirmed by prospective studies, several important clinical implications emerge. First, clinicians may be less concerned that semaglutide-induced weight loss inherently increases fracture risk in patients with type 2 diabetes
Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial
Terns Pharmaceuticals reports topline 12-week data from its phase 2 trial evaluating oral GLP-1 receptor agonist TERN-601 in obesity