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Acknowledgements The work was supported by the Monash University Ramaciotti Centre for Cryo-Electron Microscopy, the Monash MASSIVE high-performance computing facility, the National Health and Medical Research Council of Australia (NHMRC) project grants (1061044, 1065410, 1120919 and 1126857) and NHMRC program grants (1055134 and 1150083), the Japan Society for the Promotion of Science (JSPS) KAKENHI no

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Oxidative stress and mitochondrial impairment: key drivers in neurodegenerative disorders