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The two medications work through different mechanisms (Orlistat reduces dietary fat absorption in the gut, and Saxenda regulates appetite centrally)

Clinical trials reached phase II before the program was discontinued

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M., Maresh, C

Reasons for discontinuation of GLP1 receptor agonists: data from a realworld crosssectional survey of physicians and their patients with type 2 diabetes

Azadbakht and Baniasadi outlined how they hope to address these issues, noting: We are considering further research to address limitations in the current evidence base