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Dec 5 2022;doi:10.1001/jamaneurol.2022.4397

28% placebo Correlation: every 5kg weight loss -1.5 PHQ-9 points Independent effects: 40% improves weight loss, 60% provides additional mechanisms Tirzepatide SURMOUNT-1 (Mental Health Outcomes): Baseline depression (self-reported): 22% participants Improves depressive symptoms: 68% tirzepatide group vs

Prescribed at PEAK as part of a clinician-managed program

For diarrhea and constipation, it is important that patients ensure that they are having appropriate dietary fiber intake and are drinking enough water in each situation

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