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10.1016/j.freeradbiomed.2018.08.014 57 RusetskayaN
Nature 380:435439 Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS et al (2003) The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis
Epithalon has demonstrated a good safety profile in experimental and limited human studies, showing minimal adverse effects when used properly in research settings
Initially, injections may be given weekly or biweekly until levels improve, followed by maintenance doses every 1-3 months
However, some studies have reported that despite elevated Ser levels in HCC tissues, PHGDH mRNA and protein levels are significantly downregulated [267]
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