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1,2 Initially developed as antidiabetic treatments, GLP-1 RAs and, more recently, dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists have demonstrated favourable metabolic outcomes with significant and sustainable weight loss in large randomised controlled trials (RCTs) and real-world studies

5 Blood vessel lining and plaque stability When chronic inflammation is reduced, artery linings become less permeable to cholesterol, less hospitable to plaque formation, and better able to keep existing plaques stable and contained

PMID 18701638

Small, frequent sips work better than large volumes at once, since rapid gastric filling may trigger nausea in some patients

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