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For weight management , NICE technology appraisals TA875 (semaglutide/Wegovy) and TA664 (liraglutide/Saxenda) recommend these treatments for adults with: A BMI of 35 kg/m or more with at least one weight-related comorbidity, or A BMI of 3034.9 kg/m with at least one weight-related comorbidity Lower BMI thresholds (reduced by 2.5 kg/m) apply for people from Black, Asian, and other minority ethnic family backgrounds
GLP-1Rs are expressed on eosinophils and neutrophils, and GLP-1RAs can attenuate eosinophil activation and LPS-induced expression of pro-inflammatory cytokines, including IL-1, IL-1, IL-6, TNF- and IFN- (23,149,150)
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While gastrointestinal adverse events were frequent (79.6%), they were mainly transient and mild to moderate, supporting CagriSema as a highly effective future option for weight management beyond current monotherapies [78]
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