Joshua Silva, MD Nov 7, 2025 13 min read Updated: Apr 17 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As GLP-1 and GLP-1/GIP medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) continue to transform medical weight management, one question comes up repeatedly: Do these medications cause muscle lossor even muscle wasting
"The biggest thing I've seen in my practice is that patients who are obese can take these medications and have dramatic reductions in their weight, while doing it in a healthy fashion with a tolerable treatment," Dr
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Furthermore, little is known about the WL sustainability after GLP-1RAs cessation and the optimal time frame for initiating the agent post-bariatric surgery
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The safety profile of retatrutide in individuals with T2DM was also favorable [103]