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Both peptides have favorable safety profiles compared to direct HGH replacement

v Martin E, Coert JH, Flucke UE, Slooff WM, van de Sande MAJ, van Noesel MM, et al

Reciprocally, populations that are prone to obesity have been shown to have an inherently elevated desire for sweet diets [8]

Of note, ex vivo isolated islet experiments do not simulate the full range of regulation present in vivo under T2DM conditions [207], which requires further investigation to clarify

These results suggest that GIPR activation in the CNS also interacts with anorexigenic signals to reduce body weight and food intake