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While these topicals have shown promise, by nature, many arent designed to treat more severe melasma

Ostrakhovitch EA, Lordnejad MR, Schliess F, Sies H, Klotz L-O (2002) Copper ions strongly activate the phosphoinositide-3-Kinase/Akt pathway independent of the generation of reactive oxygen species

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Lower doses might provide immunomodulatory benefits while minimizing these troublesome symptoms, potentially improving treatment adherence

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