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Transferrin-bound iron (TF-Fe) gains entry into BMVECs by binding to TfR1 on the plasma membrane, initiating receptor-mediated endocytosis and subsequent encapsulation within endosomes

And any drug that influences a foundational process is going to have very widespread effects

So far, many insurance companies have been hesitant to cover GLP-1s for patients who are obese (while paying for those with diabetes)

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