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Li C, Schluesener H
FDA has approved dipeptidyl peptidase-4 (DPP-IV) resistant long-acting GLP-1s as injectable drugs for treating patients with type 2 diabetes
Complementary in vitro studies revealed that liraglutide exerted a dose-dependent inhibitory effect on the secretion of pro-inflammatory mediators, including interleukin 6 (IL-6), prostaglandin E2 (PGE2), and nitric oxide (NO), and suppressed the expression of inflammatory genes in chondrocytes and macrophages [45]
Liraglutide, a human glucagon-like peptide-1 analogue, stimulates AKT-dependent survival signalling and inhibits pancreatic beta-cell apoptosis
When GLP-1 drugs recently became a trendy talking point for their impressive weight loss efficacy, their less-than-appealing aspects also came into focus, particularly gastrointestinal side effects
Step 4: Follow-Ups for Dosage and Labs Most clinics schedule follow-ups within the first 34 weeks to adjust dosage, review labs if needed, and address any side effects
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