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A phase 1 study of pegylated recombinant arginase (PEG-BCT-100) in combination with systemic chemotherapy (capecitabine and oxaliplatin)[PACOX] in advanced hepatocellular carcinoma patients
There are several medical problems that can result in secondary carnitine deficiency, such as liver disease and kidney disease, but it may also be due to poor diet
These uses may have the backing of plausible mechanistic rationales, but none possess the robust clinical validation I would want to see in a proven protocol
4 While intravenous glutathione is sometimes suggested, research is still limited on its overall safety, and some reports point to possible side effects
This is not just a theoretical concern
For work with this compound specifically, the selectivity claim is testable and worth testing rather than assuming
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