Every dose and outcome figure comes from the Novo Nordisk trial programme (REDEFINE 1 and 2, the phase 2 dose-finding trial and the phase 1b combination study) or from their registry records
Given the known risk of quinolone antibiotics interfering with the mitochondrial topoisomerases and ETC-proteins, thereby harming mitochondrial functions 25,26 , CYS were further tested in a Seahorse XF Mito Tox Assay (Agilent) to evaluate mitotoxic risks
International Journal of Biochemistry and Cell Biology , 72, 22-30.
Sometimes the results were fine
Extended interruptions of multiple days warrant protocol reassessment
Antibiotic resistance arose from the evolutionary development of primary (antibiotic target site is not presented in bacteria strain) and secondary (genome-related and plasmid-related) resistance mechanisms in bacteria (Urban-Chmiel et al., 2022