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Every dose and outcome figure comes from the Novo Nordisk trial programme (REDEFINE 1 and 2, the phase 2 dose-finding trial and the phase 1b combination study) or from their registry records

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Given the known risk of quinolone antibiotics interfering with the mitochondrial topoisomerases and ETC-proteins, thereby harming mitochondrial functions 25,26 , CYS were further tested in a Seahorse XF Mito Tox Assay (Agilent) to evaluate mitotoxic risks

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International Journal of Biochemistry and Cell Biology , 72, 22-30.

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Sometimes the results were fine

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Extended interruptions of multiple days warrant protocol reassessment

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Antibiotic resistance arose from the evolutionary development of primary (antibiotic target site is not presented in bacteria strain) and secondary (genome-related and plasmid-related) resistance mechanisms in bacteria (Urban-Chmiel et al., 2022

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