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Flavonoids, including isoorientin, catechin, coumaric acid and kaempferol-7-O-D-glucuronide, derived from Gentiana (56), Phyllostachys nigra (57), Cryptotaenia japonica (57) and dried pomegranate concentrate powder (58) exhibit skin-whitening effects by downregulating PKA/CREB-mediated MITF expression