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P values indicated, determined by two-tailed t -test ( a ) or one-way ANOVA with Dunnetts multiple comparisons test against CTRL ( b )

This can be particularly useful when studies rely on timed administration

Specifically, MSC- Igf1r / mice had less trabecular bone as defined by a significant decrease in the percent of bone volume per tissue volume (BV/TV) ( P =0.01) and trabecular thickness (Tb.Th) ( P =0.002) relative to their wt littermates (Figure 4B)