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The stopper material can become brittle at sub-zero temperatures and may not reseal properly after thawing
But the difference between average results and exceptional results comes from everything you do between injections
10.1016/S0031-9422(02)00135-8 129 PadmavathiammaP
Arthritis Rheum (2008) 58(11):353040
Nagra RM, Becher B, Tourtellotte WW, Antel JP, Gold D, Paladino T et al
Anti-inflamatorio : reduce TNF-, IL-6, IL-1
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