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In the STEP-4 clinical trials, participants who discontinued the medication began to regain weight within a few months

The peptide binds to this G-protein coupled receptor (GPCR) with high affinity and selectivity, triggering a cascade of intracellular signaling events distinct from other growth hormone secretagogues

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This helps healthcare providers determine whether the medication is working effectively and whether the dosage should be adjusted

Subsequent advances in chemistry and automation during the 1980s and 1990s made peptide synthesis routine, Kates said, which in turn allowed researchers to produce them far more efficiently