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In animal research, increasing plasma adiponectin levels through pharmacological or genetic means has shown to alleviate obesity-induced endothelial dysfunction, hypertension, atherosclerosis, myocardial infarction, and diabetic cardiomyopathy

This approach requires medical facilities, costs significantly more per treatment, and involves blood draws and processing

Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies

10.1016/j.scitotenv.2018.09.313 2 AitkenC

Despite the potential for side effects, few physicians think that side effects will be a barrier to wider GLP-1RA adoption

A unique microglia type associated with restricting development of Alzheimers disease