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The model predicted that for 10-hour-long toxicologically relevant doxorubicin (50 M) simulations, the duration of the exposure is more important than concentration with respect to overwhelming glutathione metabolism
Modalities: Physical therapy modalities (ultrasound, electrical stimulation, laser therapy) may complement peptide effects though evidence for synergy lacking
The major limitation in clinical use of these parameters is the short half-life and rapid degradation of the ROS molecules themselves
Glutamine: a Trojan horse in ammonia neurotoxicity
Both may support the liver's stores of glutathione
the current Egrifta SV formulation (FDA 2019) reduces the daily dose to 1.4 mg/day SC
