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One possible mechanism for this primary and acquired resistance may be the presence of PSMA-negative disease, which may proliferate and become the predominant clone after elimination of PSMA-expressing cancer cells with 177Lu-PSMA-617 259

The biological mechanism is well understood, even though the exact trigger varies from person to person

While emerging data points to potential additional benefits, such as reduced inflammation or improved cancer outcomes, these possibilities are still under investigation

What Happens When Delivery Goes Wrong: Two Danger Scenarios Scenario 1: Full-strength serum after microneedling

Weekly weighing prevents getting discouraged by daily fluctuations while providing enough data points to identify trends