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"There is some data out there, but in pre-clinical models

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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

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Co-delivery with siRNA targeting BCL-2, MDR1 or other resistance genes, or with natural product chemosensitizers such as curcumin or quercetin, enables simultaneous attack on multiple survival pathways, reducing the likelihood that any single resistance mechanism will confer survival